PEP: Post-Exposure Prophylaxis

  • PEP: Post-Exposure Prophylaxis

    Timely answers for urgent exposure management

    Get rapid, expert guidance in managing healthcare worker exposures to HIV and hepatitis B and C, including recommendations on when and how to initiate PEP through our online Quick Guide for urgent occupational PEP decision-making, or from experienced clinicians on our telephone consultation service. Note that our hours have changed because of funding limitations. We cannot accept calls from unknown numbers. Please unblock your phone prior to calling the PEPline.

    Hours of operation for occupational PEP consultation are 11 a.m. – 8 p.m. EST (seven days a week). If you are trying to reach us regarding an occupational PEP question outside of these hours, please check out our PEP Quick Guide for Occupational Exposures.  

    Hours of operation for non-occupational PEP consultation are 9 a.m. – 8 p.m. EST Monday – Friday, and 11 a.m. – 8 p.m. on weekends & holidays.  

    (888) 448-4911

    See our PEP Quick Guide for answers to the most frequently asked questions.

Complete consultation on post-exposure management

We provide advice on all aspects of post-exposure prophylaxis (PEP), including:

  • Assessing the risk of exposure
  • Determining the appropriateness of prescribing PEP
  • Selecting the best PEP regimen
  • Providing follow-up testing

Advice from national experts in exposure management and care

The CCC’s consultation on exposure management has helped guide PEP decision-making for more than 15 years: 150,000 PEP consultations have been provided in the CCC’s history. Members of our clinical consultation staff, which includes Infectious Disease specialists, family physicians, clinical pharmacists, and nurses, have participated in establishing federal PEP Guidelines and treatment recommendations. Advice is based on established Guidelines and the latest medical literature.

Immediate access to PEP and bloodborne pathogen exposure information

The CCC’s consultation and advice on occupational needlesticks, splashes, and other potential exposures to HIV and hepatitis B and C is available from 9 a.m. to 9 p.m. ET every day. Our online PEP Quick Guide is always available to guide your urgent PEP decision-making.

To download and print a flyer of our services, click here.

Related Clinical Resources

Related information