Archive | PEP Tips

CCC Update to FDA Notice: Dolutegravir and Post-Exposure Prophylaxis (PEP)

**PLEASE NOTE:  This statement is now outdated. We will provide updates when additional data is available. In the meantime, please reference the HHS Perinatal  Guidelines for more information on dolutegravir in pregnancy and pre-conception: https://aidsinfo.nih.gov/guidelines/html/3/perinatal-guidelines/0** On May 30, 2018 the HHS Antiretroviral Guidelines Panels issued recommendations on the use of dolutegravir for treatment of adults and […]

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PEP Tips: Laboratory Cadaver Exposures

PEP Tips: Laboratory Cadaver Exposures A treating clinician assessing the risk of transmission for a person stuck by an instrument while handling or studying a cadaver in a laboratory setting should first check for documentation of the cadaver’s bloodborne pathogen (BBP) status. Organ procurement and transplant policy requires that all potential deceased organ donors are […]

PEP Tips: Follow-Up Testing One Year After an Exposure

PEP Tips: Follow-Up Testing After One Year There is only one scenario for which HIV antibody testing of the exposed patient is warranted at one year post exposure. If the exposed patient seroconverts to HCV Ab-positive and has sustained an exposure to a source patient who is known to be HIV-HCV co-infected, the exposed patient […]

PEP Tips: Baseline Testing

PEP Tips: Baseline Testing If the exposed patient decides to take PEP medications, the CDC recommends a complete blood count (CBC) and renal and hepatic function tests at baseline and two weeks into treatment. Reference: Updated US Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Postexposure […]

PEP Tips: Exposed Patient Testing

PEP Tip: Exposed Patient Testing The 2013 CDC occupational guidelines state that when the source patient is HIV-positive or of unknown status, the testing of the exposed patient should consist of: HIV Ab test at baseline, 6 weeks, 12 weeks, and 24 weeks after an exposure. If the clinician knows that a 4th generation HIV […]

PEP Tips: Found Needle PEP

Welcome to the CCC’s new monthly web series, PEP Tips! PEP Tips feature brief advice, recommendations, or options on post-exposure management topics that CCC consultants encounter on our PEPline. Looking for additional online resources on potential bloodborne pathogen exposures? Check out the PEP Quick Guide, the CCC’s at-a-glance guide for urgent post-exposure decision-making. PEP Tip: […]