PEP: Post-Exposure Prophylaxis

  • PEP: Post-Exposure Prophylaxis

    Timely answers for urgent exposure management

    Get rapid, expert guidance in managing healthcare worker exposures to HIV and hepatitis B and C, including recommendations on when and how to initiate PEP through our online Quick Guide for urgent occupational PEP decision-making, or from experienced clinicians on our telephone consultation service. Note that our hours have changed because of funding limitations. We cannot accept calls from unknown numbers. Please unblock your phone prior to calling the PEPline.

     

    Alert: Some calls to the PEPline using a Cisco phone may not go through. Please use another phone or cell phone. We are addressing this issue.

    Hours of operation for occupational PEP consultation are 11 a.m. – 8 p.m. ET (seven days a week). If you are trying to reach us regarding an occupational PEP question outside of these hours, please check out our PEP Quick Guide for Occupational Exposures.  

    Hours of operation for non-occupational PEP consultation are 9 a.m. – 8 p.m. ET Monday – Friday, and 11 a.m. – 8 p.m. ET on weekends & holidays.  

    (888) 448-4911
    CALL

    See our PEP Quick Guide for answers to the most frequently asked questions.

Complete consultation on post-exposure management

We provide advice on all aspects of post-exposure prophylaxis (PEP), including:

  • Assessing the risk of exposure
  • Determining the appropriateness of prescribing PEP
  • Selecting the best PEP regimen
  • Providing follow-up testing

Advice from national experts in exposure management and care

The NCCC’s consultation on exposure management has helped guide PEP decision-making for more than 15 years: 150,000 PEP consultations have been provided in the NCCC’s history. Members of our clinical consultation staff, which includes Infectious Disease specialists, family physicians, clinical pharmacists, and nurses, have participated in establishing federal PEP Guidelines and treatment recommendations. Advice is based on established Guidelines and the latest medical literature.

Immediate access to PEP and bloodborne pathogen exposure information

The NCCC’s consultation and advice on occupational needlesticks, splashes, and other potential exposures to HIV and hepatitis B and C is available from 11 a.m. to 8 p.m. ET every day. For consultation and advice on nonoccupational PEP, decision support is available from 9 a.m. – 8 p.m., Monday – Friday and 11 a.m. – 8 p.m. weekends and holidays.  Our online PEP Quick Guide is always available to guide your urgent PEP decision-making.

To download and print a flyer of our services, click here.

Related Clinical Resources

Related information

  • How are we responding to the COVID-19 pandemic?

    The NCCC is pleased to support ongoing efforts to prevent, prepare for, and respond to COVID-19 as it relates to HIV and viral hepatitis prevention and treatment, as well as substance use disorder treatment. For more information on how we can assist you, please visit our COVID-19 Response Page.