PEP Guidelines

PEP Guidelines

Federal and best-practice recommendations for post-exposure prophylaxis (PEP) decisions

The following guidelines and guidances from U.S.P.H.S, the CDC, and current literature provide information on identifying, managing, and following up on potential exposures to HIV and hepatitis B and C. To ensure timely post-exposure management and administration of HIV PEP, clinicians should consider occupational exposures urgent medical concerns.

Up-to-date Guidelines and guidances for potential exposure care

Current U.S. Public Health Service guidelines and select treatment protocols for managing exposures to HIV and hepatitis B and C. Guidelines on this page are updated in concordance with USPHS updates for each topic. We reviewed and updated these guidelines as of 4/21/16.

The CDC released updated non-occupational PEP guidelines in April, 2016.  Regimen selection and dosing information for non-perinatally exposed infants, children, and adolescents (e.g. found needles) can be found in Tables 5 and 6 on pages 31-37 of the guidelines.  The CCC is updating its guidance on management of pediatric PEP outside of the perinatal period to reflect information provided by these updated guidelines.  In the meantime, clinicians may continue to call the CCC for PEP consultation at 888-448-4911.

PEP (Post-Exposure Prophylaxis) Guidelines

  • Updated US Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Postexposure Prophylaxis, 2013
    Open PDF Open PDF | From SHEA

  • U.S. Public Health Service Guidelines for the Management of Occupational Exposures to HIV and Recommendations for Postexposure Prophylaxis, 2001
    Open Link Open Link | From The CDC MMWR

  • Appendix A: Practice Recommendations for Health-Care Facilities Implementing the U.S. Public Health Service Guidelines for Management of Occupational Exposures to Bloodborne Pathogens, 2001
    Open PDF Open PDF | From The CDC MMWR

  • Updated Guidelines for Anitretroviral Postexposure Prophylaxis After Sexual, Injection-Drug Use, or Other Nonoccupational Exposure to HIV — United States, 2016
    Open Link Open Link | From The CDC MMWR

  • CDC Guidance for Evaluating Health-Care Personnel for Hepatitis B Virus Protection and for Administering Postexposure Management, 2013
    Open PDF Open PDF | From The CDC

  • Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to HBV, HCV, and HIV and Recommendations for Postexposure Prophylaxis, 2001
    Open PDF Open PDF | From The CDC MMWR

  • Recommendations for Prevention and Control of Hepatitis C Virus Infection and HCV-Related Chronic Disease
    Open Link Open Link | From The CDC MMWR

PEP (Post-Exposure Prophylaxis) Guidances

  • New York State Guidance for HIV Prophylaxis Following Occupational Exposure
    Open PDF Open PDF | From HIVGuidelines.org
  • New York State Guidance for HIV Prophylaxis Following Non-Occupational Exposure
    Open Link Open Link | From HIVGuidelines.org
  • New York State Guidance for HIV Prophylaxis for Victims of Sexual Assault
    Open PDF Open PDF | From HIVGuidelines.org

Looking for clinical PrEP information? Visit our PrEP Guidelines and Resources page.